If your WACOM Table Pen isn't lined up properly with the cursor, here's what to do.
Press COMMAND and SPACE to search for WACOM, then click on Wacom Desktop Center:
(you might get a warning popup like this, just click on OK):
Inside Wacom Desktop Center, click on your Tablet device (Cintiq 16) and then click on Pen Calibration:
In the window that pops up, click on the Calibrate... button:
Now on your Tablet, tap the centre of each target with your pen. When you do, it will move to another corner of the screen, keep tapping the centre of each target as it appears:
Once you've done this you will see the success screen below. Make sure the pen is now lined up with the cursor when you move it, and if it is just click on the OK button:
Close the rest of the windows and you're good to go. Yay!!